Inhalational Anesthetics A wide variety of gases and volatile liquids can produce anesthesia. One of the troublesome properties of the inhalational anesthetics is their low safety margin. The inhalational anesthetics have therapeutic indices (LD50/ED50) that range from 2 to 4, making these among the most dangerous drugs in clinical use.…

Intravenous Anesthetics Intravenous anesthetics are a group of fast-acting compounds that are used to induce a state of impaired awareness or complete sedation. Commonly used Intravenous anesthetics include Propofol ,etomidate, ketamine and barbiturates BARBITURATES The three barbiturates most used in clinical anesthesia are sodium thiopental, thiamylal, and methohexital. Sodium thiopental has been…

LOCAL ANESTHETICS Local anesthetics are drugs which upon topical application or local injection cause reversible loss of sensory perception, especially of pain in a localized area of the body. It blocks generation and conduction of nerve impulses at a localized site of contact without structural damage to neurons. Loss of…